Corneal toxicity from vinblastine solution.

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Corneal toxicity from vinblastine solution.

The case is reported of a male physician who accidentally sprayed some vinblastine solution into his eyes. The resulting lesions are described.

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Brain-derived neurotrophic factor protects neuroblastoma cells from vinblastine toxicity.

Brain-derived neurotrophic factor (BDNF) and its receptors are necessary for the survival and development of many neuronal cells. Because BDNF and TrkB are expressed in many poor-prognosis neuroblastoma (NB) tumors, we evaluated the role of BDNF in affecting sensitivity to chemotherapeutic agents. We investigated the effects of activation of the BDNF-TrkB signal transduction pathway in two NB c...

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Cells from Vinblastine Toxicity Brain-derived Neurotrophic Factor Protects Neuroblastoma

Brain-derived neurotrophic factor (BDNF) and its receptors are nec essary for the survival and development of many neuronal cells. Because BDNF and TrkB are expressed in many poor-prognosis neuroblastoma (NB) tumors, we evaluated the role of BDNF in affecting sensitivity to chemotherapeutic agents. We investigated the effects of activation of the BDNF-TrkB signal transduction pathway in two NB ...

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[Corneal toxicity due to amantadine].

CASE REPORT A 64 year-old female with Parkinson disease treated with amantadine for two years who suddenly suffered bilateral corneal oedema. It was initially treated as herpetic endotheliitis without improvement as we lacked information on her chronic treatment. The corneal oedema finally resolved after withdrawing the drug. DISCUSSION Amantadine hydrochloride may produce endothelial dysfunc...

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Solution toxicity in soft contact lens daily wear is associated with corneal inflammation.

PURPOSE Contact lens-associated solution toxicity manifests as generalized, mild punctate epithelial fluorescein staining and usually is widely reported as asymptomatic, with no substantial clinical sequelae. This study examined the relationship between solution toxicity and corneal infiltrative events (CIEs) in soft contact lens daily wear. METHODS Several nonrandomized interventional clinic...

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ژورنال

عنوان ژورنال: British Journal of Ophthalmology

سال: 1978

ISSN: 0007-1161

DOI: 10.1136/bjo.62.2.97